Emotion processing is known to be impaired in psychopathy, but less is known about the cognitive mechanisms that drive this. Our study examined experiencing and suppression of emotion processing in psychopathy. Participants, violent offenders with varying levels of psychopathy, viewed positive and negative images under conditions of passive viewing, experiencing and suppressing. Higher scoring psychopathics were more cardiovascularly responsive when processing negative information than positive, possibly reflecting an anomalously rewarding aspect of processing normally unpleasant material. When required to experience emotional (...) response, by ‘getting into the feeling’ of the emotion conveyed by a negative image, higher factor 1 psychopathic individuals showed reduced responsiveness, suggesting that they were less able to do this. These data, together with the absence of corresponding differences in subjective self-report might be used to inform clinical strategies for normalising emotion processing in psychopathic offenders to improve treatment outcome, and reduce risk amongst this client group. (shrink)

Inequity has been a hallmark of the COVID-19 pandemic in the United States, especially in the sharply disproportionate impacts among people of color. Recent studies have confirmed that t...

The ectoplasmic specialization (ES) is a testis‐specific, actin‐based hybrid anchoring and tight junction. It is confined to the interface between Sertoli cells at the blood–testis barrier, known as the basal ES, as well as between Sertoli cells and developing spermatids designated the apical ES. The ES shares features of adherens junctions, tight junctions and focal contacts. By adopting the best features of each junction type, this hybrid nature of ES facilitates the extensive junction‐restructuring events in the seminiferous epithelium during spermatogenesis. (...) For instance, the α6β1‐integrin–laminin 333 complex, which is usually limited to the cell–matrix interface in other epithelia to facilitate cell movement, is a putative apical ES constituent. Furthermore, JAM‐C and CAR, two tight junction integral membrane proteins, are also components of apical ES involving in spermatid orientation. We discuss herein the mechanisms that maintain the cross‐talk between ES and blood–testis barrier to facilitate cell movement and orientation in the seminiferous epithelium. BioEssays 29: 36–48, 2007. © 2006 Wiley Periodicals, Inc. (shrink)

Surveys and routine clinical procedures applied in research protocols are typically considered only minimally risky to participants. The apparent benign nature of "minimal risk" tasks increases the chance that investigators and Institutional Review Boards (IRBs) will overlook the probability that clinical tools will identify signs, symptoms, or definitive test results that are clinically-relevant to subjects' welfare. "Minimal risk" procedures may also pose a particular hazard to participants in clinical research by increasing the therapeutic misconception because the tasks mimic clinical care (...) and are often conducted in clinical settings. Investigators should anticipate which measures could yield clinically-important findings and should describe explicit plans for data monitoring, disclosure, and follow-up. Protocols that include reliable and valid clinical measures should prompt a more detailed risk assessment by the IRB, even when the tasks meet the regulatory criteria for minimal physical, psychological, or emotional risk. (shrink)

There are many theories surrounding infant imitation; however, there is no research to our knowledge evaluating the reliability of listener perception of vocal imitation in prelinguistic infants. This paper evaluates intra- and inter-rater judgments on the degree of “imitativeness” in utterances of infants below 12 months of age. 18 listeners were presented audio segments selected from naturalistic recordings to represent in each case a parent vocal model followed by an infant utterance ranging from low to high degrees of imitativeness. The (...) naturalistic data suggested vocal imitation occurred rarely across the first year, but strong intra- and inter-rater correlations were found for judgments of imitativeness. Our results suggest salience of the infant’s vocal imitation despite its rare occurrence as well as active perception by listeners of the imitative signal. We discuss infant vocal imitation as a potential signal of well-being and as an indicator of language learning and vocal communication skills as perceived by caregivers. (shrink)

Embryogenesis requires the precise movement and reorganization of many cell and tissue types. Presumably, cell surface receptors allow cells to interact selectively with adjacent cells and with the extracellular environment, as well as initiate differentiative events by transducing appropriate signals across the plasma membrane. One cell surface component that serves as a receptor during a variety of cellular interactions is β1,4‐galactosyltransferase. Cell surface galactosyltransferase participates in diverse cellular interactions by binding its specific glycoconjugate substrate on adjacent cell surfaces or in (...) the extracellular matrix. Biochemical, immunological, and molecular probes are being used to better define cell surface galactosyl‐transferase functional in cellular interactions during fertilization, intercellular adhesion, cell migration, and growth control. (shrink)

Individual choice and freedom are repeatedly invoked in contemporary policy debates, including those with a focus on risk behaviors such as smoking and health insurance coverage. The idea of making the right choice with regard to health and well-being has been fortified by the neoliberal discourse of self-reliance, personal autonomy, and responsibility. This neoliberal view, stemming from the conceptualization of freedom of philosopher John Stuart Mill justifying the freedom of the individual in opposition to unlimited state control, holds that success, (...) good health, and favorable educational outcomes are largely due to individual effort. Correspondingly, so too is failure, including failure of.. (shrink)

In the fifth century A.D., Proclus served as head of the Academy in Athens that had been founded 900 years earlier by Plato. Proclus was the last great systematizer of Greek philosophy, and his work exerted a powerful influence in late antiquity, in the Arab world, and in the Renaissance. His treatise_ On the Eternity of the World _formed the basis for virtually all later arguments for the eternity of the world and for the existence of God; consequently, it lies (...) at the heart of neoplatonic philosophy and the controversy between pagans and Christians at the end of antiquity. Proclus’s eighteen Arguments were quoted within John Philoponus’ polemic against him, written in the sixth century; but the opening pages of the sole extant manuscript, which contained the first Argument, have been lost. In this book, Helen Lang and A.D. Macro present the seventeen Arguments preserved by Philoponus and translate them as an independent work. The first Argument, which survives in Arabic, is also included and makes this the only complete edition of _On the Eternity of the World_ since antiquity. This bilingual edition comprises the seventeen Arguments in Greek and English, along with an introduction, synopses, and detailed notes which help readers with or without Greek to understand them philosophically and historically. Two appendices complete the volume: the Arabic text of the first Argument, also with English translation and notes, and the first modern edition of an important Latin translation from the Renaissance. In a valuable introduction, Lang and Macro examine the complex history of these Arguments. Together with its excellent annotations, and English and Greek texts en face, the publication of Proclus’s _On the Eternity of the World_makes available an influential work by a major figure in the history of late Greek philosophy. (shrink)

In the present study, we examine the process through which abusive supervision impacts employee creativity. Specifically, we test whether abusive supervision is associated with lower levels of employee creativity and if this effect is mediated by employee sleep deprivation and emotional exhaustion. Results showed that abusive supervision had an indirect negative relationship with employee creativity via its impact on employee sleep deprivation and emotional exhaustion. These findings contribute to a better understanding of the negative effects of abusive supervision on employee (...) creativity and the processes by which they occur. (shrink)

The use of neural transplantation to alleviate cognitive deficits is still in its infancy. We have an inadequate understanding of the deficits induced by different types of brain damage and their homologies in animal models against which to assess graft-induced recovery, and of the ways in which graft growth and function are influenced by factors within the host brain and the environment in which the host is operating. Further, use of fetal tissue may only be a transitory phase in the (...) search for appropriate donor sources. Nevertheless, findings from our laboratory and elsewhere have made a prima facie case for successful cognitive reconstruction by graft methods. (shrink)

Cognitive deficits were produced in rats by different methods of damaging the brain: chronic ingestion of alcohol, causing widespread damage to diffuse cholinergic and aminergic projection systems; lesions (by local injection of the excitotoxins, ibotenate, quisqualate, and AMPA) of the nuclei of origin of the forebrain cholinergic projection system (FCPS), which innervates the neocortex and hippocampal formation; transient cerebral ischaemia, producing focal damage especially in the CA1 pyramidal cells of the dorsal hippocampus; and lesions (by local injection of the neurotoxin, (...) colchicine) of the granule cells of the dentate gyrus. Following chronic alcohol or lesions of the FCPS, transplants of cholinergically rich fetal brain tissue into the terminal areas (neocortex and/or hippocampus) restored performance almost to control levels, with a time course consistent with growth of the transplants and integration with host tissue; transplants of cholinergically poor fetal tissue (hippocampus) were without effect, as were transplants of cholinergically rich tissue into the region containing the nuclei of origin of the FCPS. Grafts of primary cells enriched in glia and cultured neuroblastoma cells into the terminal areas of the FCPS were equally effective, suggesting that there are multiple mechanisms by which neural transplants can restore cognitive function following diffuse cholinergic damage. In contrast, after ischaemia- or neurotoxin-induced damage to CA1 or dentate granule cells respectively, cholinergically rich fetal transplants into the damaged hippocampal formation were ineffective in restoring performance. After ischaemic damage, however, performance was restored by suspension grafts of CA1 cells but not by transplants containing CA3 pyramidal cells or granule cells; and after colchicine damage it was restored by solid grafts containing granule but not CA1 pyramidal cells. Furthermore, electrophysiological evidence has demonstrated functional, graft type-specific host-graft functional neuronal connectivity. Thus, restoration of cognitive function by neural transplants is possible after damage to either diffuse (cholinergic) or point-to-point (intrahippocampal) forebrain systems, but the transplant must be appropriate to the damage to be repaired. Because the different types of brain damage studied provide analogues of human alcoholic dementia, Alzheimer's disease, and heart attack, these results are encouraging with regard to the eventual application of neural transplant surgery to the treatment of cognitive deficits in humans. (shrink)

Experimental studies of fear conditioning have identified the effectiveness of safety signals in inhibiting fear and maintaining fear-motivated behaviors. In fear conditioning procedures, the presence of safety signals means that the otherwise expected feared outcome will not now occur. Differences in the inhibitory learning processes needed to learn safety are being identified in various psychological and psychiatric conditions. However, despite early theoretical interest, the role of conditioned inhibitors as safety signals in anxiety has been under-investigated to date, in part because (...) of the stringent test procedures required to confirm the demonstration of conditioned inhibition as such. Nonetheless, the theoretical implications of an inhibitory learning perspective continue to influence clinical practice. Moreover, our understanding of safety signals is of additional importance in the context of the increased health anxiety and safety behaviors generated by the COVID-19 pandemic. (shrink)

The present study expands on the growing literature concerning organizational politics by assessing the impact of team-level OP on employee performance outcomes as well as investigating the degree to which these effects are mediated by team conflict. The results, based on multilevel structural equation modeling with a sample of 349 employees from 78 firms in China, lent support for a cross-level mediating role for team conflict between political climate and employee performance. Further, moderator analyses demonstrated that political climate acted as (...) a condition for task conflict to trigger relationship conflict. Thus, the results of this study contribute to both the political climate literature and the conflict literature by clarifying the processes by which climate can influence employee performance. (shrink)

Within the rough ground that is the field of education there is a complex web of ethical obligations: to prepare our students for their future work; to be ethical as educators in our conduct and teaching; to the ethical principles embedded in the contexts in which we work; and given the Southern context of this work, the ethical obligations we have to this land and its First Peoples. We put out a call to colleagues whose work has been concerned with (...) the pedagogies of professional ethics, the ethical burdens of institutional injustice, and the application of ethical theory to education’s applied fields. In the responses we received it can be seen that ethical concerns in education are broad ranging, covering terrain varying from the preparation of preservice teachers, ethics in higher education, early childhood and care, educational leadership, relational and communicative ethics. Perhaps it could also be argued that this paper demonstrates Gibbon’s observation that ‘Assumptions about the particularity of this time as new and ripe with opportunity to make a difference through philosophy of education are not new and there’s much to learn from the persistence of wanting to imagine that they are’. However, while the field of ethics is perennially concerned with human relations and pedagogical interventions to improve these, the responses collected here show that educational ethics is far from static. Educational ethics is a field that continues to develop in response to changing contexts. (shrink)

Suscités par la reprise massive de la recherche en astronomie au IXe siècle dans le monde islamique et essentiellement à Bagdad, laquelle nécessite des outils mathématiques nouveaux, une floraison de traités, tant astronomiques que mathématiques, voit le jour à cette époque. D'entre les traités mathématiques, un certain nombre est consacré à la ‘‘figure secteur”, c’est-à-dire au théorème dit ‘‘de Ménélaüs” sur la sphère, lequel généralise le théorème dit ‘‘de Ménélaüs” dans le plan. Ce théorème de Ménélaüs sur la sphère, ou (...) règle des six quantités, est, en l’absence du théorème des sinus sur la sphère, lequel ne date que de la deuxième moitié du Xe siècle, le principal outil de l'astronomie sphérique. Le traité de Thābit ibn Qurra sur La figure secteur est le premier de ces traités consacrés au théorème de Ménélaüs, tant dans le plan que sur la sphère, à nous être parvenu; point de départ de tout un courant, il influencera profondément le développement ultérieur de la géométrie sphérique. Ce traité, qui est en fait une épître adressée à un correspondant malheureusement anonyme, présente en outre l'intérêt de montrer que, dans le milieu scientifique de cette époque à Bagdad, beaucoup s'intéressaient à ce théorème, essayaient d'en énoncer d'autres cas de figure et de compléter la démonstration qu'en donne Ptolémée dans l'Almageste. (shrink)

Once Apollonius' Conics had been translated from Greek into Arabic, they became a main reference and the principal tool in studying solid problems, algebraic equations of 3rd and 4th degrees, infinitesimal mathematics, etc. Mathematicians of the 9th–10th centuries also studied the conic sections' constructions, as well as their continuous drawing and their drawing by points. Ibrāhīm ibn Sinān, as his grandfather Thābit ibn Qurra, was one of the most active and inventive mathematicians in these fields. Late Hélène Bellosta examined (...) in this article Ibn Sinān's contribution.Une fois les Coniques d'Apollonius traduits en arabe, ces livres sont devenus la référence indispensable et le principal instrument dans l'étude des problèmes solides, des équations algébriques des 3e et 4e degrés, des problèmes des mathématiques infinitésimales, etc. Les mathématiciens des ixe-xe siècles ont également étudié les constructions des sections coniques ainsi que leur tracé par points et leur tracé continu. Ibrāhīm ibn Sinān, comme son grand-père Thābit ibn Qurra, était l'un des mathématiciens les plus actifs et les plus inventifs en ce domaine. Dans cet article, la regrettée Hélène Bellosta a examiné la contribution d'Ibn Sinān.Send article to KindleTo send this article to your Kindle, first ensure [email protected] is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about sending to your Kindle. Find out more about sending to your Kindle. Note you can select to send to either the @free.kindle.com or @kindle.com variations. ‘@free.kindle.com’ emails are free but can only be sent to your device when it is connected to wi-fi. ‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply. Find out more about the Kindle Personal Document Service.DE L'USAGE DES CONIQUES CHEZ IBRĀHĪM IBN SINĀNVolume 22, Issue 1Hélène Bellosta DOI: https://doi.org/10.1017/S0957423911000129Your Kindle email address Please provide your Kindle [email protected]@kindle.com Available formats PDF Please select a format to send. By using this service, you agree that you will only keep articles for personal use, and will not openly distribute them via Dropbox, Google Drive or other file sharing services. Please confirm that you accept the terms of use. Cancel Send ×Send article to Dropbox To send this article to your Dropbox account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about sending content to Dropbox. DE L'USAGE DES CONIQUES CHEZ IBRĀHĪM IBN SINĀNVolume 22, Issue 1Hélène Bellosta DOI: https://doi.org/10.1017/S0957423911000129Available formats PDF Please select a format to send. By using this service, you agree that you will only keep articles for personal use, and will not openly distribute them via Dropbox, Google Drive or other file sharing services. Please confirm that you accept the terms of use. Cancel Send ×Send article to Google Drive To send this article to your Google Drive account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about sending content to Google Drive. DE L'USAGE DES CONIQUES CHEZ IBRĀHĪM IBN SINĀNVolume 22, Issue 1Hélène Bellosta DOI: https://doi.org/10.1017/S0957423911000129Available formats PDF Please select a format to send. By using this service, you agree that you will only keep articles for personal use, and will not openly distribute them via Dropbox, Google Drive or other file sharing services. Please confirm that you accept the terms of use. Cancel Send ×Export citation Request permission. (shrink)

RésuméUne fois lesConiquesd'Apollonius traduits en arabe, ces livres sont devenus la référence indispensable et le principal instrument dans l'étude des problèmes solides, des équations algébriques des 3eet 4edegrés, des problèmes des mathématiques infinitésimales, etc. Les mathématiciens desixe-xesiècles ont également étudié les constructions des sections coniques ainsi que leur tracé par points et leur tracé continu. Ibrāhīm ibn Sinān (909–946), comme son grand-père Thābit ibn Qurra (826–901), était l'un des mathématiciens les plus actifs et les plus inventifs en ce domaine. Dans (...) cet article, la regrettée Hélène Bellosta a examiné la contribution d'Ibn Sinān. (shrink)

Ethical climate (EC) has been broadly described as how well institutions respond to ethical issues. Developing a tool to study and evaluate EC that aims to achieve sustained improvements requires a contemporary framework with identified relevant drivers. An extensive literature review was performed, reviewing existing EC definitions, tools and areas where EC has been studied; ethical challenges and relevance of EC in contemporary paediatric intensive care (PIC); and relevant ethical theories. We surmised that existing EC definitions and tools designed to (...) measure it fail to capture nuances of the PIC environment, and sought to address existing gaps by developing an EC framework for PIC founded on ethical theory. In this article, we propose a Paediatric Intensive Care Ethical Climate (PICEC) conceptual framework and four measurable domains to be captured by an assessment tool. We define PICEC as the collective felt experience of interdisciplinary team members arising from those factors that enable or constrain their ability to navigate ethical aspects of their work. PICEC both results from and is influenced by how well ethical issues are understood, identified, explored, reflected on, responded to and addressed in the workplace. PICEC encompasses four, core inter-related domains representing drivers of EC including: (1) organisational culture and leadership; (2) interdisciplinary team relationships and dynamics; (3) integrated child and family-centred care; and (4) ethics literacy. Future directions involve developing a PICEC measurement tool, with implications for benchmarking as well as guidance for, and evaluation of, targeted interventions to foster a healthy EC. (shrink)

This introduction to the Common Knowledge symposium titled “Comparative Relativism” outlines a variety of intellectual contexts where placing the unlikely companion terms comparison and relativism in conjunction offers analytical purchase. If comparison, in the most general sense, involves the investigation of discrete contexts in order to elucidate their similarities and differences, then relativism, as a tendency, stance, or working method, usually involves the assumption that contexts exhibit, or may exhibit, radically different, incomparable, or incommensurable traits. Comparative studies are required to (...) treat their objects as alike, at least in some crucial respects; relativism indicates the limits of this practice. Jensen argues that this seeming paradox is productive, as he moves across contexts, from Lévi-Strauss's analysis of comparison as an anthropological method to Peter Galison's history of physics, and on to the anthropological, philosophical, and historical examples offered in symposium contributions by Barbara Herrnstein Smith, Eduardo Viveiros de Castro, Marilyn Strathern, and Isabelle Stengers. Comparative relativism is understood by some to imply that relativism comes in various kinds and that these have multiple uses, functions, and effects, varying widely in different personal, historical, and institutional contexts that can be compared and contrasted. Comparative relativism is taken by others to encourage a “comparison of comparisons,” in order to relativize what different peoples—say, Western academics and Amerindian shamans—compare things “for.” Jensen concludes that what is compared and relativized in this symposium are the methods of comparison and relativization themselves. He ventures that the contributors all hope that treating these terms in juxtaposition may allow for new configurations of inquiry. (shrink)

We estimate that 208,000 deep brain stimulation (DBS) devices have been implanted to address neurological and neuropsychiatric disorders worldwide. DBS Think Tank presenters pooled data and determined that DBS expanded in its scope and has been applied to multiple brain disorders in an effort to modulate neural circuitry. The DBS Think Tank was founded in 2012 providing a space where clinicians, engineers, researchers from industry and academia discuss current and emerging DBS technologies and logistical and ethical issues facing the field. (...) The emphasis is on cutting edge research and collaboration aimed to advance the DBS field. The Eighth Annual DBS Think Tank was held virtually on September 1 and 2, 2020 (Zoom Video Communications) due to restrictions related to the COVID-19 pandemic. The meeting focused on advances in: (1) optogenetics as a tool for comprehending neurobiology of diseases and on optogenetically-inspired DBS, (2) cutting edge of emerging DBS technologies, (3) ethical issues affecting DBS research and access to care, (4) neuromodulatory approaches for depression, (5) advancing novel hardware, software and imaging methodologies, (6) use of neurophysiological signals in adaptive neurostimulation, and (7) use of more advanced technologies to improve DBS clinical outcomes. There were 178 attendees who participated in a DBS Think Tank survey, which revealed the expansion of DBS into several indications such as obesity, post-traumatic stress disorder, addiction and Alzheimer’s disease. This proceedings summarizes the advances discussed at the Eighth Annual DBS Think Tank. (shrink)

_Hyperdream_ is a major new novel by celebrated French author Hélène Cixous. It is a literary tour de force, returning anew to challenge necessity itself, the most implacable of human certainties: you die in the end – and that’s the end. For you, for me. But what if? What if death did not inevitably spell the end of life? _Hyperdream_ invests this fragile, tentative suspension of disbelief with the sheer force of its poetic audacity, inventing a sort of magic (...) telephone: a wireless lifeline against all the odds to the dearly departed. It is a book about time, age, love and the greatest loss. A book which turns on death: on the question or the moment of death, depending on it, expecting it, living off it, taking place at once before and after, but at the same time turning against it, contesting it, outwriting it hopefully, desperately, performatively, as an interruptible interruption. _Hyperdream_ is a book of mourning, but also of morning, a tragedy-with-comedy and a universal family romance in which it transpires that the narrator is the veritable offspring of a “treasure of literature” in the form of a bed, purchased by her mother from a certain W. Benjamin in 1934, slept on for 40 years by her brother and dreamt of by her friend “J.D.”. (shrink)

Avant avoir été accusée de lèse majesté (trahison) Kaneko Fumiko (1903-1926) avait fait cause commune avec les nihilistes coréens au Japon. À partir de ce moment, comme son amant et co-accusé coréen, elle critiquait les abus coloniaux des japonais. Il est facile de comprendre pourquoi sa position politique a souvent été comprise comme un simple effet secondaire de dévouement « pour son homme ». Comment expliquer autrement le martyr d’une Japonaise pour un homme et pour la Corée, sinon par référence (...) à sa fémininité? Kaneko n’a pas été écoutée et cette non-écoute constitue une sorte de « colonisation » de sa position. (shrink)